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Purpose of the Workshop: This workshop was held to discuss a National Human Genome Research Institute (NHGRI) proposal to initiate a new, highly interactive public research consortium to carry out a pilot project for testing and comparing existing and new methods to identify functional sequences in DNA.The premise for the workshop was as follows:


A number of computational and experimental 'wet bench' approaches have been developed to identify and characterize the encoded functional elements in genomic DNA sequence. However, no single strategy is yet able to identify all of the coding sequences in the human genome, and different approaches actually identify different, only partially overlapping sets of coding sequences. As for other sequence-based functional elements (e.g., regulatory regions, non-coding RNA sequences, elements involved in chromosome structure and function), few if any comprehensive approaches have even been devised for testing.

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