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PVDF tank
VII. HOLDING TANK
In hot systems, temperature is usually maintained by applying
heat to a jacketed holding tank or by placing a heat exchanger
in the line prior to an insulated holding tank.
The one component of the holding tank that generates the most
discussion is the vent filter. It is expected that there be some
program for integrity testing this filter to assure that it is
intact. Typically, filters are now jacketed to prevent condensate
or water from blocking the hydrophobic vent filter. If this occurs
(the vent filter becomes blocked), possibly either the filter
will rupture or the tank will collapse. There are methods for
integrity testing of vent filters in place.
IX. PIPING
Piping in WFI systems usually consist of a high polished stainless
steel. In a few cases, manufacturers have begun to utilize PVDF
(polyvinylidene fluoride) piping. It is purported that this piping
can tolerate heat with no extractables being leached. A major
problem with PVDF tubing is that it requires considerable support.
When this tubing is heated, it tends to sag and may stress the
weld (fusion) connection and result in leakage. Additionally,
initially at least, fluoride levels are high. This piping is of
benefit in product delivery systems where low level metal contamination
may accelerate the degradation of drug product, such
 Please Contact Us to discuss your PVDF tank
needs. You design it, we build it.
PVDF
tank
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